Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload

Lead Poisoning Disturbs Oligodendrocytes Differentiation Involved in Decreased Expression of NCX3 Inducing Intracellular Calcium Overload

Lead (Pb) poisoning has always been a serious health concern, as it permanently damages the central nervous system. Chronic Pb accumulation in the human body disturbs oligodendrocytes (OLs) differentiation, resulting in dysmyelination, but the molecular mechanism remains unknown. In this study, Pb at 1 μM inhibits OLs precursor cells (OPCs) differentiation via decreasing the expression of Olig ...

Prevention of intracellular calcium overload

Role of intracellular Ca2+ overload in inducing changes in cardiac gene expression

Institute of Cardiovascular Sciences, St Boniface Hospital Research; Department of Physiology & Pathophysiology, College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba Correspondence: Dr Naranjan S Dhalla, Institute of Cardiovascular Sciences, St Boniface Hospital Research, 351 Tache Avenue, Winnipeg, Manitoba R2H 2A6. Telephone 204-235-3417, fax 204-237-034...

Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes.

Heavy marijuana use has been linked to white matter histological alterations. However, the impact of cannabis constituents on oligodendroglial pathophysiology remains poorly understood. Here, we investigated the in vitro effects of cannabidiol, the main nonpsychoactive marijuana component, on oligodendrocytes. Exposure to cannabidiol induced an intracellular Ca(2+) rise in optic nerve oligodend...

CNTF protects oligodendrocytes from ammonia toxicity: intracellular signaling pathways involved.

In pediatric patients, hyperammonemia can provoke irreversible damages to developing CNS like cortical atrophy, ventricular enlargement, demyelination or gray and white matter hypodensities which are concordant with alterations of neurons and oligodendrocytes. Cerebral injury triggers endogenous protective mechanisms that can prevent or limit brain damage. Understanding these mechanisms may lea...